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Chromosulfuric acid is a corrosive oxidation reagent composed of a mixture of concentrated sulfuric acid and dichromate. The acid can be used to clean laboratory glassware of otherwise insoluble organic residues and has a variety of industrial applications.
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A dopamine metabolite; formed via deamination of dopamine by MAO to produce DOPAC followed by DOPAC metabolism by COMT; undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer with ex/em = 312/420 nm, respectively; has been used to quantify hydrogen peroxide production in macrophages and neutrophils
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An oxidized form of ascorbic acid; inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83% at 0.5 and 1 mM, respectively; increases GPX and glutathione reductase activity and inhibits ROS production in hydrogen peroxide-treated astrocytes at 1 mM; increases cerebral blood flow and reduces infarct volume and mortality in a mouse model of cerebral ischemia-reperfusion injury induced by transient MCAO when administered prior to ischemia at 40 and 250 mg/kg; reduces infarct volume in a permanent MCAO mouse model when administered pre- or post-ischemia at 250 and 500 mg/kg, respectively
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A NSAID and COX-2 inhibitor; binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid in vitro (Ki = 10 µM); reduces acetic acid-induced writhing in rats at 30 mg/kg; inhibits DNBC-induced increases in skin thickness in a mouse model of delayed-type hypersensitivity; reduces the antibody response to sheep red blood cells in mice
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Chemical. CAS 81377-14-2. Formula C6H3ClN2O4S . NH3. MW 251.65. Ammonium 4-chloro-7-sulfobenzofurazan SBF-Cl is a water-soluble fluorogenic reagent which is highly specific for thiol groups. SBF-Cl is a very good substrate for the investigation of glutathione S-transferases GST. Used as a hematology and histology stain and in diagnostic assay manufacturing. Spectral data lambdaex 360 nm lambdaem 410 nm pH 8.5 lambdaex 383 nm lambdaem 528 nm Reaction product.
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An intermediate in the synthesis of ursodeoxycholic acid by intestinal bacteria in humans; increases the bile flow rate and the concentration of bile bicarbonate in rats via venous infusion at 1.2 µmol/min per 100 g body weight; levels are decreased in rat feces in a model of adenine-induced chronic renal failure; fecal levels are also reduced in patients with liver cirrhosis or hepatocellular carcinoma
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A halogenated form of lauric acid; has been used in the synthesis of clickable forms of myristic acid and as a model fatty acid ligand to determine the X-ray crystal structure of bovine β-lactoglobulin-ligand complexes; reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of HBV infection at 10 UG/ml and inhibits HIV replication in CEM-SS T cells (EC50 = 38 µM)
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